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| Genome Characterization Centers
Genomics is a fast-moving field with novel technologies and characterization platforms being made available to the research community on a continual basis. The Cancer Genome Atlas (TCGA) Genome Characterization Centers (GCCs) are responsible for characterizing all of the genomic changes found in the tumors studied as part of the TCGA program. The GCCs will use multiple platforms, including array technologies and second generation sequencing, to provide data to the cancer research community on alterations in miRNA and gene expression, single nucleotide polymorphisms and copy number changes. The GCCs will also be working to validate specific regions of interest through targeted sequencing.
The TCGA Genome Characterization Centers, by area of focus, are:
Copy Number Alteration (Single Nucleotide Polymorphism Characterization):
| Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass. |
| Principal Investigators: |
Raju Kucherlapati, Ph.D.
Lynda Chin, M.D.
Jonathan Seidman, Ph.D. |
| The Broad Institute, Cambridge, Mass. |
| Principal Investigators: |
Matthew Meyerson, M.D., Ph.D.
Stacey Gabriel, Ph.D. |
Epigenomics:
University of Southern California, Los Angeles
Johns Hopkins University, Baltimore, Md. |
| Principal Investigators: |
Peter Laird, Ph.D.
Stephen Baylin, M.D. |
Gene (mRNA) Expression:
| University of North Carolina, Chapel Hill, N.C. |
| Principal Investigators: |
Chuck Perou, Ph.D.
Neil D. Hayes, M.D., M.P.H.
Jason Lieb, Ph.D. |
miRNA Analysis:
| British Columbia Cancer Agency, Vancouver |
| Principal Investigator: |
Marco Marra, Ph.D. |
Targeted Sequencing Center:
| Baylor College of Medicine, Houston, Texas |
| Principal Investigators: |
David Wheeler, Ph.D.
Richard Gibbs, M.D, Ph.D.
Rui Chen, Ph.D. |
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